Sick sinus syndrome (SSS) refers to the damage of the sinoatrial node and its surrounding tissues, which leads to the excitation and conduction dysfunction of the sinoatrial node, resulting in a series of arrhythmia diseases. It is of great value to better explore the pathogenesis of SSS, provide a basis for its treatment research, and establish an animal model that can simulate human sinus node dysfunction. In this paper, the selection of animals, the principles and methods of modeling, the evaluation methods and detection indicators of the model were reviewed, hoping to provide a basis for further study of the pathogenesis of SSS.