Huntington’s disease (HD) is a type of autosomal dominant neurodegenerative disease, where the main symptoms in patients include chorea-like involuntary movements, psychiatric behavioral abnormalities, and cognitive impairments, severely affecting their lives and consuming extensive social and medical resources. To better understand the pathological mechanisms and explore treatment methods, a variety of HD experimental animal models have been successfully established. This article outlines the establishment and application of various animal models ranging from Caenorhabditis elegans, Drosophila melanogaster and zebrafish to mice, rats and miniature pigs, and analyzes the characteristics and advantages of different animal models. By reviewing different animal models and their relevant evaluation indicators, this article emphasizes the importance of utilizing a combination of multiple animal models to promote a deeper understanding of the disease mechanisms and develop effective treatment strategies.