【】 Objective: By comparing the cerebral blood flow, the morphological changes of nerve cells in brain tissue and the levels of serum oxidation and inflammatory factors in three different rat models of cerebral hypoperfusion, the experimental animal models were provided for the study of mechanisms and therapeutic drugs of cerebrovascular diseases and neurodegenerative diseases. Method: A total of 88 male SD rats were randomly divided into sham operation group (n=16), classic bilateral common carotid artery occlusion group (2-VO group, n=24), modified 2-VO group (n=24) and intraluminal thread technique group (n=24). Bilateral common carotid artery ligation was performed in the classic 2-VO group, while blood was drawn from the common carotid artery before ligation in the modified 2-VO group (1mL/100g). Middle cerebral artery occlusion was performed in the intraluminal thread technique group. In the sham operation group of the first two models, the common carotid artery was separated but not ligated, while the proximal end of the common carotid artery and the external carotid artery were ligated but not insert the bolt thread in the sham group of intraluminal thread technique model. Cerebral blood flow, infarct volume, serum inflammatory factor level, HE staining and ultrastructure of hippocampal tissue were measured at 1, 3 and 7 days after operation. Results: Laser speckle showed that the cerebral blood flow of rats of the three groups decreased rapidly after surgery, and then increased slowly. The decrease of cerebral blood flow of the modified 2-VO group was more obvious than that of the other two groups. At day 7, only the modified 2-VO group still had significant differences in cerebral blood flow compared with the sham group, and remained in a state of hypoperfusion (cerebral blood flow decreased by 30% compared with the operation). The results of TTC staining showed that the infarcts in the striatum of the three groups gradually increased with the extension of the time after operation, among which 4 rats (about 26.7%) in the modified 2-VO group had infarcts in both the cortex and striatum, while 10 rats (about 66.7%) in the intraluminal thread technique group. ELISA showed that the levels of inflammatory factors like TNF-α, IL-1β and hs-CRP in the three groups were increased after operation, and the levels of pro-oxidation factors ROS were also increased. In contrast, the level of antioxidant factor SOD decreased. At postoperative day 7, there was no significant difference in hs-CRP between the classic 2-VO and the intraluminal thread technique groups compared to the sham group. However, the modified 2-VO group still exhibited significant differences in all the above indicators compared to the sham group. HE staining showed that the modified 2-VO group caused more severe damage to the hippocampal CA1 and CA3 regions compared to the classic 2-VO and the intraluminal thread technique groups. Transmission electron microscopy demonstrated that the modified 2-VO group induced more severe damage to mitochondrial and endoplasmic reticulum in the hippocampal region compared to the the classic 2-VO and the intraluminal thread technique groups. Conclusion: Compared to the classic 2-VO and the intraluminal thread technique, the modified 2-VO method can induce more complete cerebral hypoperfusion and more severe neural damage within the same time frame, resembling the pathogenesis of human cerebral hypoperfusion more closely.