Depression is a common mental illness at present,which brings a negative impact on the quality of life of patients, but also brings a serious economic burden to the society. In recent years, the strategy of interfering with depression based on signaling pathways has attracted widespread attention in society. As an important cellular signaling pathway, the cAMP pathway plays a key role in the pathogenesis and intervention of depression. Therefore, this review addresses recent studies on cAMP pathway-based interventions in depression, which provides a theoretical basis for regulating the cAMP pathway and its cascade mechanism on depression.