【Abstract】 Prostate cancer is a prevalent malignant tumor within the male genitourinary system, characterized by a high propensity for bone metastasis. It is a leading cause of mortality, with approximately 70% of deaths attributed to this form of metastasis. Mouse models serve as a crucial tool in the investigation of prostate cancer""s bone metastasis, playing a pivotal role in elucidating the underlying pathophysiological mechanisms and in the development and assessment of therapeutic agents. In this review, we summarized the research progress of prostate cancer bone metastasis mouse models, construction methods, and evaluation strategies used in establishing mouse model. Particularly, this review emphasizes the exploration of the development mechanisms behind prostate cancer bone metastasis using mouse models. It aims to offer significant insights and serve as a valuable reference for f prostate cancer bone metastasis.