The impact of ginger-processed Jiangxiangru polysaccharides on the establishment of a breast cancer mouse model and its pathological characteristics
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1.Science&Technology Center for Experimental Animal of Jiangxi University of Chinese Medicine,Nanchang;2.Clinical Medical College of Jiangxi University of Chinese Medicine,Nanchang

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The Science and Technology Project of Jiangxi Provincial Department of Education (GJJ180661), the school-level science and technology innovation team development plan of Jiangxi University of Traditional Chinese Medicine is: No. CXTD-22004。

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    Abstract:

    Objective: To observe the combined characteristics of symptoms in breast cancer-bearing mice and the improvement effect of ginger-processed Jiangxiangru polysaccharides on their traditional Chinese medical symptoms. Methods: A total of 38 experimental mice were used for modeling and then divided into six groups, designated as the normal group, model group, positive group, and low, medium, and high dose groups of ginger-processed Jiangxiangru polysaccharides. The normal group was not inoculated with tumors, and both the normal and model groups were given physiological saline intragastrically; the positive group was given celecoxib solution intragastrically; the low, medium, and high dose groups of ginger-processed Jiangxiangru polysaccharides were given the same dose but different concentrations of ginger-processed Jiangxiangru polysaccharide solution intragastrically. After 4 weeks of continuous administration, the changes in mouse weight and tumor size were recorded. At the end of the experiment, the symptoms of breast cancer-bearing mice were observed. By collecting photographs of the tongues, tails, and claws of mice from each group, the RGB values of the mice's tongues, tails, and claws were analyzed and recorded. Based on the method of quantitative dialectical diagnosis, the degree of blood deficiency, yin deficiency, and tumor phlegm stasis was calculated. The tumors were isolated, weighed, and the tumor volume and inhibition rate were calculated to explore the improving effect of ginger-processed Jiangxiangru polysaccharides on the traditional Chinese medical symptoms of mice. Results: The breast cancer model group mice showed signs of blood deficiency, yin deficiency, and phlegm stasis. The group administered ginger-processed Jiangxiangru polysaccharides significantly reduced tumor size. Ginger-processed Jiangxiangru polysaccharides could inhibit tumor growth and had an improving effect on the degree of blood deficiency, yin deficiency, and tumor phlegm stasis constitution in breast cancer-bearing mice, with the high dose group showing the best results. Conclusion: Ginger-processed Jiangxiangru polysaccharides have an improving effect on the constitution of blood deficiency, yin deficiency, and tumor phlegm stasis in breast cancer-bearing mice, with the high dose group showing the best results.

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History
  • Received:August 24,2024
  • Revised:April 22,2025
  • Adopted:April 30,2025
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