Alzheimer's disease (AD) is a common neurodegenerative disease. Traditional Chinese medicine is effective in treating AD. The combination of disease and syndrome with animal model is the basis and premise of related research. In this paper, studies on non-transgenic AD animal models and AD disease and syndrome combined animal models are summarized. It was found that, there are eight common non-transgenic AD animal models, including aging type (natural aging type, rapid aging type, induced aging type) and injection-induced damage type (Aβ injection animal model, Tau damage type, cholinergic system damage model, neuroinflammation model, and aluminum poisoning induction model). AD syndromes combined with animal models include kidney deficiency/kidney deficiency/kidney deficiency pulp empty, phlegm turbidity blocking orifice, blood stasis blocking collaterals, phlegm stasis interlocking, liver depression and phlegm fluid stagnation heat. In this paper, the advantages and disadvantages of each model replication method are reviewed, in order to provide reference and support for the future study of AD disease and syndrome combined with animal models.