Research Progress on the Construction of Rat Models with Elevated Blood Pressure Variability
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1.College of Pharmacy, Gansu University of Traditional Chinese Medicine;2.College of Basic Medicine, Gansu University of Traditional Chinese Medicine;3.Cardiovascular Medicine,Department,Ping Liang Second People'4.'5.s Hospital

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Funded by Gansu Province Higher Education Innovation(2021A-080), Gansu Province Education Technology Innovation (2022A-068),Open Fund Project of Key Laboratory of Traditional Chinese Medicine Pharmacology and Toxicology in Gansu Province(ZDSYS-KJ-2024-003).

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    Abstract:

    The increased of blood pressure variability(BPV) plays important role in the occurrence and development of target organs such as heart, brain, kidney and blood vessel damage in hypertensive population, controlling BPV is an effective method to reduce the incidence of cardiovascular events and mortality in patients with hypertensive.Through literature mining and collation, this article reviews the construction methods and model characteristics of rat models with increased BPV, in order to provide references for experimental research and clinical precise medication.

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History
  • Received:April 07,2025
  • Revised:July 30,2025
  • Adopted:November 27,2025
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