Objective: To investigate the effect and mechanism of Tianma Qiongling Zhixuan tablets on the kidneys of spontaneously hypertensive model mice.Method: SHR rats were purchased as spontaneously hypertensive model rats, and WKY rats were used as normal blood pressure control rats. After adaptive feeding, the rats were divided into four groups: 1) Control group (WKY rats); 2) Model group (SHR rats); 3) Model+TZZT group (SHR rats+Tianma Qiongling anti glare tablets); 4) The Model+Valsartan group (SHR rats+valsartan) was administered orally with Tianma Qiongling Zhixuan tablets and Valsarta for intervention in groups 3 and 4, respectively. Blood pressure was measured before and after intervention in each group of rats. ELISA and biochemical kits were used to detect TNF - α and GSH, and a biochemical analyzer was used to detect four renal function parameters (creatinine, urea nitrogen, urea, and urinary microalbumin). HE staining and TUNEL staining were used to detect the degree of kidney tissue damage and cell apoptosis, and immunofluorescence was used to detect the expression of NF - κ B P65, p-P65, SIRT1, and PGC-1 α in kidney tissue.Result: The levels of TNF - α in the serum of spontaneously hypertensive rats increased, while the levels of GSH decreased. The levels of creatinine, urea nitrogen, urea, and microalbumin in urine increased. After oral administration of Tianma Qiongling Zhixuan tablets and Valsartan, the systolic blood pressure of rats significantly decreased, while the diastolic blood pressure showed a decreasing trend but not significant, indicating that Tianma Qiongling Zhixuan tablets and Valsartan have a hypotensive effect; The content of TNF - α in rat serum decreased, while the content of GSH increased. The levels of creatinine, urea nitrogen, urea, and microalbumin in rat urine decreased, indicating that Tianmaqongling Zhixuan tablets and Valsartan can inhibit the release of inflammatory factors, suppress oxidative stress, and enhance renal function. The expression of NF - κ B P65 and p-P65 in the kidney tissue of spontaneously hypertensive rats increased, while the expression of SIRT1 and PGC-1 α decreased. After intervention with Tianma Qiongling Zhixuan Tablets and Valsartan, the expression of NF - κ B P65 and p-P65 decreased, while the expression of SIRT1 and PGC-1 α increased. This indicates that Tianma Qiongling Zhixuan Tablets and Valsartan can increase the expression of SIRT1 and PGC-1 α, inhibit the activation of the NF - κ B pathway, and thus suppress the inflammatory response.Conclusion: Tianma Qiongling Zhixuan Tablets can have a protective effect on the kidneys of spontaneously hypertensive rats, by increasing the expression of SIRT1 and PGC-1 α in the kidneys of spontaneously hypertensive model rats, reducing the expression of NF - κ B P65 and p-P65, and inhibiting inflammation related reactions.