【Abstract】 Premenstrual syndrome belongs to the category of "premenstrual and postmenstrual symptoms" in traditional Chinese medicine. Premenstrual dysphoria is a serious subtype of premenstrual syndrome. It is a common endocrine disorder in women of childbearing age. It seriously affects the physiological, psychological and social functions of women of childbearing age. The information transmission between neurons depends on the change of neural circuit structure, namely synaptic plasticity, and synaptic plasticity also directly or indirectly participates in the occurrence and development process of PMS/PMDD. This article is on induction of Chinese medicine (Including compound, Chinese patent medicine, monomer components) through the regulation of synaptic plasticity treatment PMS/PMDD experimental research results at the same time, focus on sorting out the contents related to the existence of synaptic plasticity abnormalities during PMS/PMDD attack, clarify that the possible way of traditional Chinese medicine intervention PMS/PMDD is to achieve the ultimate goal of inhibiting the occurrence of PPMS/PMDD by regulating the activity level of HPA axis, regulating the transcription and expression of BDNF gene, increasing the synthesis of neuroplasticity-related proteins, etc.