Abstract:Alcoholic liver disease (ALD) is a general term for a series of liver diseases caused by long-term heavy drinking, including alcoholic fatty liver disease, alcoholic hepatitis, and alcoholic cirrhosis. In order to study the pathogenesis and development of ALD and its treatment options, there is an urgent need for widely used and convenient ALD models to explore its pathogenesis and treatment strategies. In past studies, many well-established animal models of ALD have been recognized.However, the commonly used animal models are not able to fully replicate the development of human diseases.This article reviews the construction and research progress of animal models of alcoholic liver disease, in order to provide reference for future research.