Objective The aim of this study was to construct minipig models of ischaemic stroke and haemorrhagic stroke with high clinical relevance, to assess the feasibility of minipigs as in vivo models of stroke by monitoring the pathophysiological processes of the disease development after two types of strokes, and to provide a more accurate experimental tool for the study of stroke mechanisms and the development of therapeutic strategies.Methods The HS model and IS model were constructed by injecting autologous blood (twice injection method) and cranial vascular electrocoagulation, respectively. Behavioural assessment, physiological and biochemical indexes, and histopathological analysis of brain tissue, as well as immunohistochemical verification of neuronal markers were carried out in the model pigs after surgery to comprehensively assess the similarity between the models and the clinical stroke development process.Results IS model pigs showed severe hemiparesis, motor disorders and reduced conscious response, obvious ischemic necrosis of brain tissues, intense inflammatory response, significant neuronal apoptosis, and mild impairment of liver and kidney functions; HS model pigs showed mild behavioural disorders, stable haematoma formation, accompanied by cerebral oedema and mechanical compression, active inflammatory response, and obvious neuronal damage and glial cell activation.Both models showed good stability and reproducibility.Conclusion In this study, we successfully constructed IS and HS minipig models with high clinical relevance, verified the feasibility and accuracy of constructing stroke models in minipigs, and provided an experimental basis for the development of targeted therapeutic strategies with high clinical relevance and experimental value, which can help to promote the development of precision stroke therapy.