灵长类巨细胞病毒慢性潜伏再激活诱导免疫衰老的研究进展
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作者单位:

(1. 哈尔滨医科大学附属第一医院干部病房,哈尔滨 150001; 2. 解放军总医院国家老年疾病临床医学研究中心,北京 100039; 3. 中国医学科学院医学实验动物研究所,北京协和医学院比较医学中心,北京 100021)

中图分类号:

R-33


Research progress on chronic latent reactivation of primate cytomegalovirus⁃induced immune senescence
Author:
Affiliation:

(1. Department of Geriatric, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China. 2. National Clinical Research Center for Geriatric Disease, Chinese PLA General Hospital, Beijing 100039. 3. Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS); Comparative Medicine Center, Peking Union Medical College (PUMC), Beijing 100021)

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    摘要:

    巨细胞病毒(cytomegalovirus,CMV)免疫潜伏再激活可以诱导T 细胞进而发生免疫衰老已成为衰老的公认机制之一?在免疫活性宿主体内,CMV 一旦感染可在骨髓中静默潜伏,通过分化依赖性活化刺激进入循环传播,保持终生持续感染的能力?本文针对人类和非人灵长类CMV 感染后免疫状况?免疫逃避机制以及与免疫衰老相关性等方面进行比较和综述,以期为今后免疫衰老模型构筑?疫苗研制和药物开发提供基础?

    Abstract:

    Reactivation of cytomegalovirus ( CMV) can induce T cells to undergo immune senescence, a mechanism of aging. After CMV infection of immunocompetent hosts, it persists in bone marrow. CMV is stimulated and propagates into circulation via differentiation?dependent reactivation throughout life. This article compares and reviews the immune status of human and nonhuman primates after CMV infection, the immune escape mechanisms, and the relationship with immune senescence. Such information may provide a basis for establishing models of immune senescence and the development of drugs and vaccines.

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王宇虹,曲光瑾,肖冲,邓巍.灵长类巨细胞病毒慢性潜伏再激活诱导免疫衰老的研究进展[J].中国比较医学杂志,2018,28(7):124~128.

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  • 收稿日期:2018-02-02
  • 在线发布日期: 2018-08-08
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