基于中西医临床病证特点的宫颈癌动物模型分析
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1.河南中医药大学药学院,郑州 450046;2.河南省重大校企研发中心,郑州 450046

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R737. 33;R-332;R273

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Analysis of cervical cancer animal models based on clinical characteristics of traditional Chinese and Western medicine
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1. College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China. 2. Henan Major University-Enterprise Joint R&D Center, Zhengzhou 450046

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    摘要:

    宫颈癌发病呈年轻化趋势,严重危害女性生命健康,目前针对该病仍缺乏显著有效的治疗方 案。为推进宫颈癌临床诊治的发展,筛选出符合宫颈癌病证特点的动物模型十分重要。总结现有宫颈癌动物模型,主要包括自发性宫颈癌、诱发性宫颈癌、移植性宫颈癌以及基因工程性宫颈癌等动物模型。基于宫颈癌中西医临床病证特点对各模型赋值进行分析,发现移植性宫颈癌动物模型的中西医吻合度相对较高,其中皮下移植法西医临床吻合度达 70%且最为常用,宫颈原位移植法中医临床吻合度达 68. 5%;自发、诱发性宫颈癌 模型造模成功率不高,模型间差异大,且吻合度不高,较少使用。总体来看,模型中医临床吻合度均较低,不利于宫颈癌的中西医结合诊治发展,故又提出施加中医致病因素、中医模型评判标准等建议,以期完善宫颈癌模 型发展,推动临床疾病研究。

    Abstract:

    Cervical cancer (CC) exhibits a relatively young age of onset and represents a severe danger to women’s life and health; however, there is currently a lack of effective therapeutic regimens for this disease. The development of clinical diagnostic and therapeutic approaches for CC require the screening of animal models that conform to the clinical syndrome characteristics of CC. Existing animal models of CC mainly include spontaneous, induced, transplanted, and genetically engineered CC. The analysis of each of these models based on the clinical syndrome characteristics of CC in traditional Chinese and Western medicine ( TCM-WM) showed that transplanted transplantation method had a Western medicine clinical consistency of 70% and was the most commonly used, while the orthotopic cervical transplantation method had a TCM clinical consistency of 68. 5%. Spontaneous and induced models were less frequently used because of low modeling-success rates, significant inter-model differences, and poor consistency. Overall, the TCM consistency of all models was relatively low, which is not conducive to the development of integrated TCM-WM diagnosis and treatment approaches for CC. Therefore, applying TCM pathogenic factors and establishing TCM model-evaluation criteria are required to improve the development of CC models and promote clinical disease research.

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朱潘婷,任梦阳,田 硕,白 明,曹利华,苗明三.基于中西医临床病证特点的宫颈癌动物模型分析[J].中国比较医学杂志,2026,36(12):80~92.

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  • 在线发布日期: 2026-07-23
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