Recent intensive promulgation of policies on New Approach Methodologies (NAMs) by international regulatory agencies has engendered considerable cognitive uncertainty regarding whether the discipline of laboratory animal science may ultimately be supplanted. From a pedagogical perspective, this article substantiates the irreplaceability of intact animal models in recapitulating inter-organ crosstalk, systemic immune responses, comprehensive toxicokinetic profiling, and reproductive-developmental processes. It underscores the inherent predictive blind spots of current in vitro NAMs systems and emphasizes that the safety gatekeeping function of animal models, together with their indispensable role in cultivating systematic scientific reasoning, cannot be circumvented. In essence, these new policies represent conditional optimizations targeted at specific pharmaceutical categories and testing modalities. Consequently, NAMs should be positioned as supplementary tools. It is recommended that core curricula centered on animal models be retained as the foundation, with validated NAMs tools integrated in an expanded capacity, thereby establishing an integrated teaching framework that synergistically combines virtual demonstrations, live animal experimentation, and computational data analysis.