Objective: The distribution characteristics of the modeling factors and of the detection indicators that have been reported in the literature concerned with the construction of animal models of osteonecrosis of the femoral head, both within China and internationally, were systematically analyzed in the present study, in order that a methodological reference of practical value might be provided for the establishment of stable and reliable animal models of this disease and for the conduct of the related experimental research. Methods: Literature related to animal experiments on osteonecrosis of the femoral head that had been indexed over the course of the most recent ten years was retrieved from seven databases, namely the China National Knowledge Infrastructure, the Wanfang Database, the VIP Chinese Science and Technology Journal Database, the China Biology Medicine Database, PubMed, Web of Science, and Embase. From each of the publications that were included, the key information was extracted, comprising the species, the sex, the age expressed in weeks, and the body weight of the experimental animals, together with the modeling method, the modeling period, the hormone dose, the detection indicators, positive intervention drug, and the traditional Chinese medicine syndrome model that had been adopted. A database was constructed by means of Microsoft Excel 2021, and statistical analysis was subsequently carried out with the assistance of Origin 2022, SPSS Modeler 18.0, and Cytoscape 3.10.4. Results: A total of 758 publications were ultimately included in the present analysis. It was found that sexually mature Sprague-Dawley rats and New Zealand rabbits were the animals most frequently selected for the preparation of the models, and that the male sex constituted the majority among the animals that were employed. Hormone-induced approaches predominated among the modeling methods and accounted for 80.34% of the included models, among which the combination of lipopolysaccharide with methylprednisolone, or the single-factor regimen in which methylprednisolone was administered alone, was the most commonly applied. The hormone doses used for model induction ranged from 20 to 40 mg/kg, and the modeling periods fell within two ranges: from 2 to 7 days and from 31 to 56 days. The detection indicators mainly included histopathological changes, bone mass and bone microstructural parameters, imaging abnormalities of the femoral head, and tissue protein and gene expression levels. Among the drugs that were employed for positive intervention, those derived from traditional Chinese medicine reached a proportion as high as 62.08%. Conclusion: It is indicated by these findings that a relatively large number of methods are at present available for the preparation of animal models of osteonecrosis of the femoral head; nevertheless, a systematic evaluation based on traditional Chinese medicine syndromes is still lacking, and a unified and generally recognized modeling method has not yet been established. By means of the data mining of animal models of osteonecrosis of the femoral head that has been carried out in the present study, it is hoped that theoretical support and a reference basis may be provided for the selection and evaluation of ONFH animal models in future research.