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黄甘泉.降压物质检查试验中家猫对组胺灵敏度分析[J].中国比较医学杂志,2020,30(6):83~87.
降压物质检查试验中家猫对组胺灵敏度分析
Histamine sensitivity analysis of domestic cats for the examination of depressor substances
投稿时间:2019-06-03  
DOI:10. 3969 / j.issn.1671-7856. 2020. 06. 012
中文关键词:  降压物质检查  家猫  灵敏度  重复使用
英文关键词:examination of depressor substances  cats  sensitivity  reuse
基金项目:
作者单位E-mail
黄甘泉 广东省医学实验动物中心,佛山 528248 847833864@ qq.com 
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中文摘要:
      目的 分析降压物质检查中家猫的血压及其对组胺的灵敏度数据,为家猫的使用提供参考。 方法 家猫联合麻醉后,按《中国药典》降压物质检查法测量家猫颈动脉血压和对不同剂量组胺的灵敏度并对数据进行分 析。 结果 本研究中家猫血压和对组胺的灵敏度与体重无相关性,组胺所致家猫血压反应值与血压成正比,血压值在 16~ 18 kPa 范围的家猫可重复使用次数最高。重复用于药品降压物质检查 6 次,家猫血压和对组胺灵敏度未见明显降低(P> 0. 05);与首次使用比较,第 7、8 次重复使用家猫血压显著下降(P < 0. 05),第 8 次重复使用时对组胺灵敏度显著下降(P< 0. 05),但仍满足《中国药典》降压物质检查法对家猫灵敏度的要求。 结论 家猫血压和 对组胺灵敏度较稳定,可多次重复使用于降压物质检查试验。
英文摘要:
      Objective To calculate and analyze blood pressure data and histamine sensitivity of domestic cats on examination of depressor substance, and to provide a reference for the use of cats in experiments. Methods Blood pressure and histamine sensitivity were measured in domestic cats using the test method described in the Appendix of China Pharmacopoeia ( edition 2015) after analyzing the combined anesthesia data. Results Blood pressure and histamine sensitivity measurements were not correlated with body weight, whereas histamine sensitivity was correlated with blood pressure in this study. Furthermore, cats with blood pressure within the range of 16 ~ 18 kPa had a greater capacity for repeat examinations of depressor substances. Blood pressure and histamine sensitivity measurements did not decrease during the first six rounds of experiments. While blood pressure decreased significantly on the seventh and eighth rounds (P < 0. 05), and histamine sensitivity decreased on the eighth round (P < 0. 05), compared with data from the first round, the result still met the requirements of China Pharmacopoeia. Conclusions Blood pressure and histamine sensitivity measurements in cats were relatively stable, suggesting that examinations of depressor substances can be performed repeatedly in domestic cats.
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