关于建立子痫前期大鼠小鼠模型的研究进展
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作者单位:

1.青海大学研究生院,西宁 810016; 2.青海大学附属医院妇产科,西宁 810001

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R-33

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Research progress on the establishment of rat and mouse models for preeclampsia
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1.Graduate School of Qinghai University, Xining 810016, China. 2. Department of Obstetrics and Gynecology, Qinghai University Affiliated Hospital, Xining 810001

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    摘要:

    子痫前期( preeclampsia, PE)是妊娠期独有的一种疾病,是导致孕产妇和围产儿发病和死亡的主要原因之一。 其病因不明,终止妊娠是目前已知的有效治疗方法。 随着社会的进步,人类对妊娠安全的要求逐渐增高,理想 PE 动物模型的建立无疑能为研究其病因、发病机制从而更好地预防或延缓疾病进展,降低 母胎死亡率提高妊娠安全提供良好的基础和平台。 大、小鼠因其经济、易获取、生存力强、妊娠周期短,所以被广泛应用于临床各大疾病动物实验中。 参考国内外文献将 PE 大、小鼠模型归纳为子宫血流量减少、炎症 免疫过度激活、血管内皮细胞损伤、血液高凝、基因修饰等模型,并就这类模型的构建方法及表型做一简要综述。

    Abstract:

    Preeclampsia (PE) is a disease of pregnancy and one of the leading causes of maternal and perinatal morbidity and mortality. Its etiology is unclear, and termination of pregnancy is known to be an effective treatment. However, there is an increasing focus on pregnancy safety. The establishment of an optimal PE animal model would provide a good foundation for the study of PE etiology and pathogenesis. This would help to prevent or delay disease progression, reduce maternal and fetal mortality, and improve pregnancy safety. Because of economy of use, easy access, strong survival ability, and short gestation period, rats and mice are widely used in animal experiments on clinical diseases. Referring to domestic and foreign literature, rat and mouse models of PE are summarized according to pathogenesis or generating method , including decreased uterine blood flow, overactivation of inflammatory immunity, vascular endothelial cell injury, blood hypercoagulability, and genetic modification. The construction method and phenotypes of rat and mouse models of PE are briefly reviewed.

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何岑盈,谢莹莺,徐梦婷.关于建立子痫前期大鼠小鼠模型的研究进展[J].中国比较医学杂志,2020,30(10):110~116.

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  • 收稿日期:2020-02-27
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  • 在线发布日期: 2020-11-25
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