Abstract:Long non-coding RNAs (lncRNA) are a novel class of RNA molecules that are extensively involved in tumor development and progression. The testis developmental related gene 1 (TDRG1) lncRNA is aberrantly expressed in a variety of cancers, influences tumor proliferation, invasion, and metastasis by different mechanisms, and is closely correlated with patient prognosis. In this paper, we will review the biological effects of TDRG1 on tumors and the underlying molecular mechanisms.