Primary biliary cholangitis ( PBC) is an incurable rare autoimmune liver disease with low incidence and an unclear pathogenesis. Studies have shown that external environmental factors have led to a yearly increase in incidence. Therefore, it is of great significance to establish an animal model with similar pathogenesis to study the pathogenesis and treatment of PBC. After reading relevant domestic and foreign literature over the past 20 years, we summarized the method to establish PBC animal models induced by various exogenous substances. Various exogenous (2- OA-BSA, polyI:C, N. aromaticivorans, AMA antigen and BDP ) and analyze the characteristics of various modeling method. Induction method of PBC animal models are summarized and the characteristics of various modeling method were analyzed. We provide a reference for researchers to choose more suitable animal models, explore the pathogenesis of PBC and develop new drugs.