| 刘继红,邵思迈,赵振荣,史 洺,郝 莉,张紫娟,张振强.Nrf2-ARE 信号通路在帕金森病中的作用[J].中国比较医学杂志,2022,32(4):145~150. |
| Nrf2-ARE 信号通路在帕金森病中的作用 |
| The role of the Nrf2-ARE pathway in Parkinson’s disease |
| 投稿时间：2021-06-28 |
| DOI：10. 3969 / j.issn.1671-7856. 2022. 04. 021 |
| 中文关键词: 帕金森病 氧化应激 Nrf2-ARE |
| 英文关键词:Parkinson’s disease oxidative stress Nrf2-ARE |
| 基金项目: |
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| Author Name | Affiliation | E-mail | | LIU Jihong | Medical School, Henan University of Chinese Medicine, Zhengzhou 450046, China | ljh15736783819@ 163.com | | SHAO Simai | Medical School, Henan University of Chinese Medicine, Zhengzhou 450046, China | | | ZHAO Zhenrong | Medical School, Henan University of Chinese Medicine, Zhengzhou 450046, China | | | SHI Ming | Medical School, Henan University of Chinese Medicine, Zhengzhou 450046, China | | | HAO Li | Medical School, Henan University of Chinese Medicine, Zhengzhou 450046, China | | | ZHANG Zijuan | 1. Medical School, Henan University of Chinese Medicine, Zhengzhou 450046, China. 2. College of Traditional Chinese Medicine, Henan University of Chinese Medicine, Zhengzhou 450046 | | | ZHANG Zhenqiang | 1. Medical School, Henan University of Chinese Medicine, Zhengzhou 450046, China. 2. College of Traditional Chinese Medicine, Henan University of Chinese Medicine, Zhengzhou 450046 | zhang_zhenqiang@ 126.com |
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| 中文摘要: |
| 核因子 E2 相关因子 2( nuclear factor erythroid-2 related factor2,Nrf2) / 抗氧化反应元件( antioxidant response element,ARE)信号通路是一种受氧化还原信号调节的重要抗氧化通路,其通路的激活在调控氧化应激、维持线粒体功能、抑制多巴胺能神经元铁死亡及恢复神经元功能等方面发挥重要作用,已逐渐成为近几年来帕金森病(Parkinson’s disease,PD)研究的热点。 本文通过对近些年有关 Nrf2-ARE 通路的结构、功能及其在 PD 治疗中作用机制的实验结论进行分析、总结,为进一步明确其与氧化应激在 PD 发生发展中的关系、开发新的靶向 Nrf2-ARE 通路的 PD 相关治疗药物提供思路。 |
| 英文摘要: |
| The nuclear factor erythroid-2-related factor2 (Nrf2) / antioxidant response element (ARE) signaling pathway is an essential antioxidant pathway regulated by redox. Activation of this pathway plays an important role in regulating oxidative stress, maintaining mitochondrial function, inhibiting ferroptosis in dopaminergic neurons and ptotecting them against oxidative damage. Targeting this pathway for the treatment of Parkinson’ s disease ( PD) has become a research focus. In this review, we summarize and analyze the current research on the Nrf2-ARE pathway, including the mechanisms, function and relation with PD. These insights may help further clarify the relationship between Nrf2-ARE pathway and PD and aid in developing new ideas for new PD drugs targeting the Nrf2-ARE pathway. |
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