Study on the Xenograft of two Human Carcinoma Cell Lines in SCID and BALB/c nude Mice
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Q26 R735

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    Abstract:

    Two human carcinoma cell lines, MDA-MB-231 breast cancer a nd LAX-83 lung adenocarcinoma cell lines were xenografted in scid (severe combin ed immunodeficiency mice) and BALB/c nude mice. MDA-MB-231 cells were subcutaneo usly injected into different parts (including breastpad and costal region) adn L AX-83 only one part (costal region) of the animals. Results showed that the tota l survival rates of two cell lines were 100% (21/21) in scid, 57.1%(8/14) in BAL B/c-nu. There was asignificant difference between two strains (P0.05). In the test of MDA-MB0231 transplantation, the Rates of lung metastasis were 100%(5/5), lymphatic metastasis 20%(1/5) with the breastpad injection, lung metastasis 50% (2/4) with costal injection in scid, and only 20% (1/5) of the lung metastasis c ould be observed with the costal injection in BALB/c-nu. In LAX-83 test, all of the carcinoma in scid did not disapear naturally. But 50% (1/20 did from BALB/c-nu. Studies suggested that scid was still better su ited for being an animal model of tumor experiments than BALB/c-nu, especially f or orthotopic transplantation of the breast cancers.

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