Objective To discuss achievement ratio and mortality rate of preparation of porcine model of biliary cirrhosis,and seek methods to evaluate hepatic function reserve.Methods Choosing ten common pigs as experimental animal,cutting the belly open,dissociating and ligating common bile duct, during the course of the experimental procedure,we collect samples and measure portal venous pressure regularly.Results The rate of success is 100 percent and the rate of mortality is 40 per cent.ALT and AST go up step by step in the early stages,then go steady.TBIL increases continuously,on the contrary,albumin decreases continuously.Conclusion Rate of success of model of hepatic cirrhosis is more higher and time which is needed is shorter,but the rate of mortality is more higher.Pathology biopsy is still a gold standard of diagnosing fibrosis at present.The changes of ALT and AST have no significance for evaluating the development of hepatic cirrhosis.Albumin and bilirubin have obviously difference in before-and after-liver cirrhosis,which is useful to evaluate liver cirrhosis,but sensibility is poor,we should take active in seeking more valuable indexes.