CHEN Xi
Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Beijing Insititute for Brain Disorders, Beijing 100053, ChinaGU Hong-shun
Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Beijing Insititute for Brain Disorders, Beijing 100053, ChinaLI Lin
Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Beijing Insititute for Brain Disorders, Beijing 100053, ChinaSchizophrenia is a common and serious mental disorder, which causes great harm to patients and their families. Because of the complicated pathogenesis of schizophrenia, there are still many problems in its drug treatment. Stable and reliable animal models are required for preclinical studies of new drugs. In this article, we reviewed the rodent models associated with positive symptoms, negative symptoms and cognitive impairment of schizophrenia and the behavioral evaluation on these models, hoping to provide useful references of animal models for the antipsychotic drug screening and preclinical studies.
