Phagocytic function of microglia and underlying regulatory mechanism in neurodevelopment and neurodegenerative diseases
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(1. Key Laboratory of Human Disease Comparative Medicine, National Health and Family Planning Commission of P. R. C, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Comparative Medicine Center, Peking Union Medical College, Beijing 100021,China. 2. Neuroscience Center, Chinese Academy of Medical Sciences, Beijing 100730)

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R-33

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    Abstract:

    Microglia, a type of neuroglia, has a variety of functions such as phagocytosis, clearance, antigen presentation, promotion of repairment of injury and secretion of extracellular signaling molecules, in which phagocytosis of microglia plays a crucial role in maintaining brain tissue, remodeling synapses, clearance of several aberrant proteins such as amyloid β in neurodegenerative diseases, and in neurodevelopment. This review briefly summarizes the phagocytic function of microglia with underlying regulatory mechanism in neurodevelopment and neurodegenerative diseases, aiming to provide a new thought for the therapy of neurodegenerative diseases.

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History
  • Received:July 27,2017
  • Revised:
  • Adopted:
  • Online: May 22,2018
  • Published: