Endometriosis is a benign, chronic, and common gynecologic disease in the clinical setting. Antioxidants have been applied as drugs and health care products because of their antioxidant, anti-inflammatory, and antiaging properties. The antagonistic effects of antioxidants on endometriosis can reportedly be assessed by measurement of the total antioxidant status and total oxidant status, volumes of endometriotic tissues, levels of inflammatory cytokines, neovascularization, apoptosis, and other parameters, which might lead to the establishment of a novel treatment for endometriosis. However, further studies are needed to determine the exact effects and mechanisms.