Research progress on rabbit model of cerebral hemorrhage
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(The First Affiliated Hospital of Soochow University, Suzhou 215000, China)

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R-33

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    Abstract:

    Rabbits have similar evolutionary history to primates, similar cerebral vascular morphological features to humans, and easily localized basal ganglia. Moreover, as their success rates for cerebral hemorrhage modeling are high, while long-term mortality is low, rabbits are considered to be an ideal research model of cerebral hemorrhage. At present, there are several method for inducing a rabbit cerebral hemorrhage model: ① autologous blood injection, ② collagenase induction, ③ trauma, and ④ caused by puncturing middle cerebral artery. Whether the model has been successfully established can be assessed through the following aspects: behavioral analysis, gross anatomy, imaging, pathology, and so on. And the successfully established models can be used to study the pathophysiological mechanisms of cerebral hemorrhage and early diagnosis method , and to explore new treatment method , etc. This article mainly reviews the rabbit model of cerebral hemorrhage.

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  • Received:
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  • Online: December 10,2019
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