Establishment and research progress of a frozen shoulder animal model
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Affiliation:

1.Nanjing University of Chinese Medicine, Nanjing 210023, China. 2. Affiliated Hopspital of Integrated Traditional Chinese and Western Medicine,Nanjing University of Traditional Chinese Medicine, Nanjing 210028. 3. Jiangsu Province Academy of traditional Chinese Medicine, Nanjing 210028

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R-33

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    Abstract:

    Frozen shoulder is a chronic, self-limited disease of shoulder joints. However, the etiology and pathogenesis are still unclear. Its main pathological changes are shoulder capsule contracture, thickening, fibrosis, and chronic synovitis. Recently, animal models have had an important role in investigating the pathogenesis, treatment, and prevention of frozen shoulder. Animal models using rats, mice, dogs, and rabbits with different modeling method have been widely used for frozen shoulder research by domestic and foreign scholars. However, each animal model of frozen shoulder has advantages and limitations based on specific research interests. In this paper, the modeling method of several typical frozen shoulder animal models are reviewed and discussed in detail. Research progress in the pathogenesis of frozen shoulder disease based on these method is also discussed. This review is expected to provide useful ideas for basic research and clinical medical exploration of frozen shoulder

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History
  • Received:October 12,2019
  • Revised:
  • Adopted:
  • Online: August 19,2020
  • Published: