As an important vertebrate model organism, zebrafish are widely used in research fields such as developmental biology. With the rapid development of zebrafish research, experimental zebrafish housing must be standardized and should facilitate zebrafish husbandry. Here, we systematically discuss the construction of zebrafish facilities, including the automatic breeding system and the building design and renovation. The zebrafish breeding system uses modern industrial automation technology to provide a safe and suitable environment for zebrafish growth and breeding. Suitable zebrafish facilities should integrate the breeding system with the building structure.