Cardiovascular disease currently accounts for more than 30% of all deaths. In patients with cardiovascular disease, acute myocardial infarction is usually the first manifestation and may progress to heart failure. In addition, the human heart has low regeneration ability, which causes the irreversible loss of myocardial cells and persistent tissue scars. This inevitably causes serious pathological sequelae. New treatments for myocardial regeneration are urgently required. This article summarizes recent research, including the role of inflammatory responses, in myocardial regeneration and provides direction towards the realization of human myocardial regeneration.