With the development of microsurgery method , flap transplantation technology has become increasingly beneficial. To explore the characteristics of the blood supply of flaps, improve the survival rate of flaps, and improve microsurgery technology, many animal models of flaps have been established to simulate the physiological status of flaps in vivo during clinical applications. To date, models of flaps have been established in different animal species with their own advantages and disadvantages. However, there have been no comprehensive summaries of the current state of the field of experimental animal models of flaps. Therefore, we reviewed the current research progress in the field of experimental animal models of skin flaps.