Lung cancer is a malignant tumor with high mortality and morbidity and causes great harm to human health. Traditional Chinese medicine (TCM) has extensive clinical experience in the prevention and treatment of malignant tumor, and it also shows clear advantages in the treatment of lung cancer. Experimental animal models are an essential part of the lung cancer research field. The construction of the animal model of disease and syndrome combination with TCM characteristics is based on the the theory of syndrome differentiation and treatment in TCM, and the TCM symptoms are included in the evaluation criteria, so that the animal model conforms to the characteristics of western medicine disease and has the characteristics of TCM symptoms. This review summarizes the method and characteristics of commonly used lung cancer animal models and disease syndrome combination models to provide a reference for researchers engaged in lung cancer experimental research.