Ultrasound imaging for evaluation of nodular goiter in rats
Received:May 05, 2022  
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DOI:10. 3969 / j.issn.1671-7856. 2023. 01. 010
KeyWord:thyroid disease; animal models; model evaluation; ultrasound probing
高祥举 1.山东中医药大学中医学院,济南 ;2.山东中医药大学情志病证研究创新团队,济南 ; 3.山东中医药大学情志病证肝藏象药理青年科研创新团队,济南
高冬梅 1.山东中医药大学中医学院,济南 ;2.山东中医药大学情志病证研究创新团队,济南
陈宪梅 1.山东中医药大学中医学院,济南 ;2.山东中医药大学情志病证研究创新团队,济南 ; 3.山东中医药大学情志病证肝藏象药理青年科研创新团队,济南
宋婷婷 .山东中医药大学情志病证研究创新团队,济南 ; 3.山东中医药大学情志病证肝藏象药理青年科研创新团队,济南 ;4.山东中医药大学药学院,济南
高 占 1.山东中医药大学中医学院,济南 ;2.山东中医药大学情志病证研究创新团队,济南 ; 3.山东中医药大学情志病证肝藏象药理青年科研创新团队,济南
高 杰 1.山东中医药大学中医学院,济南 ;2.山东中医药大学情志病证研究创新团队,济南
王杰琼 2.山东中医药大学情志病证研究创新团队,济南 ; 3.山东中医药大学情志病证肝藏象药理青年科研创新团队,济南 ;4.山东中医药大学药学院,济南
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       Objective To determine localization of the rat thyroid gland by ultrasound technology, analyze and evaluate lesions and the degree of modeling in the rat nodular goiter model, and provide a technical method for diagnostic evaluation of the rat model of nodular goiter and related thyroid diseases. Methods Forty 6 ~ 8 weeks old SPF-grade Wistar rats (male and female) were used as the control group and 20 rats were instilled with a propylthiouracil (PTU) solution for 8 weeks to establish a rat model of nodular goiter. Ultrasound examination of the thyroid gland was performed after modeling, along with pathological examination for comparison with ultrasound. Results Ultrasonography showed that the anterior-posterior and medial-lateral diameters of the thyroid gland in the model group were significantly larger than those in the control group (P<0. 001). Conversely, asymmetric enlargement of the gland was observed in the model group. The shape and size of thyroid tissue and the follicle size were irregular in HE-stained thyroid glands of the model group. In the group, epithelial cells were obviously hyperplastic, disorganized and unevenly distributed with compressed colloid. Ultrasound and pathological tests were consistent with the disease diagnosis. Conclusions Ultrasound is a good method for in vivo evaluation of a rat nodular goiter model.
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