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| Effects of N-methyl-D-aspartate receptor NR2B phosphorylation on ischemic / hypoxic neuroprotection |
| Received:March 05, 2022 |
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| DOI：10. 3969 / j.issn.1671-7856. 2023. 01. 016 |
| KeyWord:NMDA; NR2B; ischemic / hypoxic; phosphorylation; neuroprotection |
| Author | Institution |
| 刘晓蕾 |
1.包头医学院药学院,内蒙古 包头 ;2.内蒙古自治区低氧转化医学重点实验室,内蒙古 包头 ; 3.泰国格乐大学国际学院公共卫生学系,泰国 曼谷 10220 |
| 姜树原 |
1.包头医学院药学院,内蒙古 包头 ;2.内蒙古自治区低氧转化医学重点实验室,内蒙古 包头 ; 3.泰国格乐大学国际学院公共卫生学系,泰国 曼谷 10220 |
| 邵 国 |
2.内蒙古自治区低氧转化医学重点实验室,内蒙古 包头 ; 3.泰国格乐大学国际学院公共卫生学系,泰国 曼谷 10220;4.深圳市龙岗区第三人民医院转化医学中心检验科,广东 深圳 |
| 谢雅彬 |
内蒙古自治区低氧转化医学重点实验室,内蒙古 包头 |
| 贾小娥 |
内蒙古自治区低氧转化医学重点实验室,内蒙古 包头 |
| 谢 伟 |
2.内蒙古自治区低氧转化医学重点实验室,内蒙古 包头 ; 3.泰国格乐大学国际学院公共卫生学系,泰国 曼谷 10220 |
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| Abstract: |
| N-methyl-D-aspartate (NMDA) receptor plays an important role in the function of the nervous system. The NR2B subunit is the regulatory subunit of NMDA receptor, which is closely related to the neuroprotection of hypoxia / ischemia. Phosphorylation of NR2B is considered to be an important mechanism to regulate the NMDA receptor function and plays an important role in ischemic / hypoxic neuroprotection through the change in phosphorylation. This review discusses the development of the NR2B subunit of NMDA receptor and the relationships between the structure, function, phosphorylation, signaling pathway and ischemic / hypoxic neuroprotection to provide a theoretical foundation to prevent and treat hypoxic / ischemic brain diseases with NR2B subunit as the target. |
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