In trauterine surgery were performed at 116-125 gestational days in 16 ewes for the insertion of vesicular catheters at fetal abdominal aorta from femoral artery or shin artery,to build an animal model of fetal distress induced by injected microsphere 0.5ml into the vesicular catheter of fetal abdominal aorta once per 15 minutes.The results indicated that many microspheres appeared in small artery of placenta,two placental tissues around vesicular which was blocked with microsphere was showed degeneration and necrosis.Brain tissue in test group showed acute pathologic changes of degeneration and necrosis.It was suggested that injection of microsphere from fetal abdominal aorta can model the process of fetal distress,and companying neural damaged.