Aim:To study the relationship between left ventricular hypertroply and blood pressure and myocardial local angiotensin II (AngII) in Spontaneosly hypertive rats(SHR). Methods:Male SHR and WKY were decapitated at 4wks, 8wks, 12wks, 24wks and 36wks. Systobic blood pressure (SBP) and left ventricle mass to body weight ratio (LVM/BW) were measured. The myocardial Ang II concentration were masured by radioimmunoassay. The liner regression between SBP, Ang II content and LVM/BW was performed. Result:Left ventricular mass positively correlated with SBP(r=0.65 P<0.05) and Ang II concentration(r-0.71 P<0.05). Conclusion: These data strongly suggested that myocardial local AngII and blood pressure may play an important role in left ventricular hypertrophy in SHR.