Objective: In the recent study , the learning and memory function, open field behavior and motor function were investigated in the rats which's bilateral carotid arteries were ligatured for 1 and 4 months. Method water maze, open field and climb rope test were applied after the rat's bilateral carotid arteries were ligatured 1 and 4 months. Results In the water maze test , the ability of learning and memory in rats after 1 and 4 months decreased significantly. In open field test, their spatial cognitive ability decreased significantly and excitability increased significantly. The ability of climb rope in the rat after operation 4 months. Conclusions The ability of learning and memory in the rats which's bilateral carotid arteries were ligatured damaged permanently, and excitability of animal increased significantly, but motor function was normal.