Jingchu Rheumatism Ointment was applied to the skin of laboratory rabbits for six consecutive months in order to observe its long-term toxic reaction. The results showed:(1)The rabbits in all ointment groups(O) and in all blank ointment groups (B) didn't die during the experiment.Their behaviour,activity,hair, feces were not found abnormal.Their food-intake and body weight were without any obvious variation;(2) After the experiment periods of three months and six months, the hematology examination of rabbits in all Ogroups and in all B groups was not made with distinct difference;(3) The blood biochemical measurement values in Ogroups and in B groups were basically similar;(4) When the systematic thanatopsia of laboratory rabbits,one rabbit each in a high-dose O group and a B group demonstrated 2-3 yellow-white circular nodes as large as a green bean in lingula pulmonis sinistri.Ohter organs were not found of obvious pathologic changes;(5)With the histopathology examination, the pathologic change of lung tissue seem by naked eyes was a focal suppurative inflammation (abscess) under microscope.The results indicated no toxicity of the ointment inunction for six months.