Objective To search for a new method to determinate the bone remodeling ability of bone morphogenetic protein(BMP).Methods Self-prepared bovine morphogenetic protein (bBMP)with same weight was buried in the muscles of the behind legs of the mouse.The place which bBMP was buried in was examined with ultrasonography,X-ray and histological section at 3,5,7,14,21,28 day after the operation respectively.Results No new bone was found by ultrasonography and X-ray at 3,5,7,14 day and the signs of new bone appeared at 21,28 day.By histological method a large number of mesenchymal cells were seen in the muscles in which bBMP was buried at 3,5,7 day,and the formation of new cartilage and the new bone at 14 day,then the normal bone developed at 21,28 day.Conclusion The results of B-mood ultrasound and X-ray and histological section were almost the same.So it seems feasible that B-mood ultrasound is regarded as a new method to determine the bone induction ability of bBMP.