Through reviewing recent experimental resear ch literature of asthma in foreign countries,a comprehensive analysis is carried out from selecting experimental animals in commom use for asthma researches to essential factors of preperation of an animal model in research work.At present d ay,the guinea pig is still the wildly used experimental animal for asthma experi ment,while the use of rats and mice is increasing day by day.On the basis of the data of literature,the property of all kinds of methods is assessed and the imp roved method is described.The detailed exposition is given to the application of animal model of asthma in the researches of mechanisms of asthma onset,especial ly the cytokines of immmne system which are related with the mechanisms.It is em phasized that experimental animals should be sensitized and chanllenged accordin g to different clinical types and purposes of the researcher.