Objective To study the effects of chemical medicine combined with immunopotentiator on sarcoma 180 Cells.Methods Kunming mice were used as laboratory animal models which were all with sarcoma 180 cells transplanted subcutaneously. Test group was administered FK309 combined with BCG. Then the authors did the ordinary blood test and serumal biochemical test,observed pathological tissue slices,and calculated inhibition rate of the growth of tumor. Results Total protein and albumin of test group were higher than those of control group. Examination of tissue slices showed that necrotic degree of tumor of test mice was worse than that of controls. The inhibition rate of sarcoma on the fifth,tenth,fifteenth days was 14.3%, 21.4% and 36.4% respectively. Statistical assay indicated that there was no significant difference (P<0.05) between the mean weight of tumor of both groups until the fifteenth day(P<0.05) . The mean weight of mice had no conspicuous difference.Conclusion FK309 with BCG may be of value in the inhibition of the development of tumors.