Objective To observe the effect of new drug Xisichuan on experimental asthma in guinea pigs. Methods Experimental asthma models were induced by acetylcholine and histamine nebulization or ovalbumin injection investigated. Results and Conclusion Xisichuan has distinct bronchic dilatation effect on acetylcholine and histamine induced guinea pigs model. It can partly prevent the bronchial constriction induced by ovalbumin immune sensitivity in guinea pigs.