Objective To study the distribution and morphology of 5-HT pisitive immunoreactive endocrine cells in the digestive tract of %Oryctolagus cunieulus% rabbits by the method of immunhistochemistry technique. Methods The method of the ABC immunhistochemistry technique was performed. Results There was negative reaction in esophagus and cardiac part, and positive reaction in the other parts. The cells' distribution of density was as !M". The shape of 5-HT positive immunoreactive endocrine cells was round and ellipse mainly, but shuttle with process in small intestine part and tapering in rectum. The cells were found in between epithelial cells and between gastric glands, but in the lamina propria in rectum. Conclusion The feeding habit and digestive character of %Oryctolagus cunieulus% rabbits affect the distribution of 5-HT positive immunoreactive endocrine cells in some extent, the morphology of 5-HT positive immunoreactive endocrine cells are conformable with the endocrine and exocrine functions.;