大鼠右室肥厚模型的制作及右心导管法测定大鼠右室压
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R541 R-332


A Rat Model of Right Ventricle Hypertrophy
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    摘要:

    目的 探讨大鼠右室肥厚模型的制作及心导管法测定大鼠右室压。方法 将大鼠肺动脉环缩增加其右心室后负荷,并经颈外静脉插入自制的右心导管测定右室压力上升的程度。结果 肺动脉环缩6周后,实验组右室游离壁体积及重量均明显增加;组织学检查显示明显右室肥厚的病理变化。结论 用肺动脉环缩的方法可成功建立大鼠右室肥厚的动物模型。

    Abstract:

    Objective To evaluate the method of making a right ventricle hypertrophy model in rats and measure rats' right ventricular pressure by catheterization. Method Pulmonary artery banding was performed in male rats of approximately 250g. Right ventricle catheterization was carried out through right external jugular vein in order to monitor the right ventricular pressure and the relationship between this pressure and the degree of banding. Results Right ventricle hypertrophy appeared in all rats by six weeks of banding. The weight of right ventricle free wall was significantly increased(p<0.01). Marked pathological changes of ventricle hypertrophy were observed under light and electron microscope. Conclusion A right ventricle hypertrophy model was successfully created through our methods.

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鲁亚南 丁文祥 陈恩 蒋祖明 邹文艳.大鼠右室肥厚模型的制作及右心导管法测定大鼠右室压[J].中国比较医学杂志,2004,(1):31~34.

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