This paper summarizes recent progress in transgenic swine in Biotech Institute of Hubei Academy of Agriculture Science. The Seven individual foreign genes with different construction, that is, POMT-PGH, PSV40-PGH, POMT-PGH-Micro satellite DNA, PMHR, hDAF, pBHSA, pSHSA, was microinjected into 4027 embryos. 83 founders were produced. Transgenic rate was 0.9 to 3.4% and 2.2% on average. Through improving main technological process, we improved transgenic rate, established the technology of hybrid in situ of chromosome, detection of foreign gene quantity by PCR and Dot blot and Southern blot and Northern blot for expression protein, investigated the genetic regulation of transgenic swine.