Objective To investigate the effects of Xiaoyao nose dripping liquid on the behavior and symptoms of experimental rat migraine model. Methods Fifty Wistar rats were randomly divided into 5 groups, each of 10 rats: normal control, model group, taijitongtiankoufuye liquid given orally group, Xiaoyao nose dripping liquid given orally group and Xiaoyao nose dripping liquid dripped into nose group. The experimental migraine model rats were duplicated by modified method reported by Tassorelli. The created rat models were given corresponding drugs and their changes of behaviors and symptoms were continuously observed at various time intervals. Result The symptom amelioration by Xiaoyao nose dripping liquid dripped into nose group was significantly better than Xiaoyao nose dripping liquid and taijitongtiankoufuye taken orally groups. Conclusion Xiaoyao nose dripping liquid may significantly improve the symptoms of migraine.