Objective To establish a rat model of hypercholesterolemia,and examine whether oral administration of extracts of Ampelopis grossedentata and Lotus leaf(EAGLL) can reduce level of TC of rat.Methods\ 50 rats of hypercholesterolemia were divided randomly into five groups: low dose group of EAGLL 5 mg/kg,moderate dose group of EAGLL 10 mg/kg,high dose group of EAGLL 20 mg/kg,model control group fed with a high cholesterol diet,medicine group of oral cholesterol-reducing medicine 180 mg/kg.All test groups of were administrated continuously for 28 days.TG,TC,HDL-C,weight,fat and Lee's index were measured.Results\ Blood biochemical analysis showed TC value was lower after EAGLL administration than before in the moderate and high dose groups(P<0.05).Lee's index was lower in high dose group than in model control group(P<0.05).Conclusion\ EAGLL decreased value of cholesterol and Lee's index of rat model of hypercholesterolemia.