Objective To set up a type 2 diabetes mellitus SD rat model.Methods SD rats were fed on a diet enriched in fat and fructose for 4 weeks to induce insulin resistance.The rats were injected intrapertoneally with a low-dose streptozocin(STZ) once(30 mg/kg) to induce hyperglycemia after 2 weeks.Results Insulin sensitivity index was decreased significantly in control group and hypertension was seen after rats were fed on a diet enriched in fat and fructose.There were hyperglycemia,fast blood insulin increased and lower insulin sensitivity in rat models after STZ injection.Conclusion The experiment test provided an ideal type 2 diabetes mellitus SD rats model.