筛选妊娠糖尿病巨大儿大鼠模型的新方法
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R587.1


Screening of Gestational Diabetes Mellitus Models with Macrosomia in Rats: A New Approach
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    摘要:

    目的建立妊娠糖尿病巨大儿大鼠模型。方法SD雌性大鼠腹腔注射链脲佐菌素(streptozotoein,STZ)25mg/kg,之后与同系雄性大鼠合笼见栓者定为孕0d。孕6d测定血糖高出孕前20%者为模型组(M组),与正常对照组(C组)继续妊娠至孕21d行剖腹产术,分离胎鼠。结果M组胎鼠体重、身长、尾长均显著大于C组(均P〈0.001)、胎鼠血糖高于C组(P〈0.001)。结论腹腔注射25mg/kg STZ后挑选孕6d血糖高于孕前20%者可复制妊娠糖尿病巨大儿大鼠模型。

    Abstract:

    Objective To establish gestational diabetes mellitus model with macrosomia in rats Methods\ 7 days after being injected STZ 25mg/kg intraperitoneally,Female SD rats were mated with the male.On the day 6 of conception,plasma glucose(PG) levels were determined and those whose PG level increased by 20% than that before pregnancy were selected as the Model(M) group.All rats were c-sectioned on the day 21 of pregnancy to observe the fetuses.Results\ Body weights,body lengths,tail lengths of the offspring in M group were significantly heavier or longer than those in C group(P<0.001).Fetal plasma glucose concentrations in M group were higher than those in C group and the statistic difference was noted(P<0.001).Conclusion\ 7 days after being injected STZ 25 mg/kg intraperitoneally,GDM rats with 20% increase of plasma glucose levels on the day 6 of conception than before pregnancy can produce macrosomia.

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毕晶珠,蒋文跃.筛选妊娠糖尿病巨大儿大鼠模型的新方法[J].中国比较医学杂志,2006,(1):25~28.

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  • 收稿日期:2004-09-24
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