Wnts家族是重要的细胞信号分子，在细胞的增值、分化及肿瘤的发生中发挥蘑要作用。Wnt配体通过与细胞膜上的两种受体分子相互作用发动信号传导。Wnt受体包括Frizzled受体家族和LDL相关蛋白家族。Wnt的拈抗剂分为两类，sFRP类和DKK类。sFRP类的成员包括sFRP、Wif-1和Cerberus，他们直接与Wnt配体结合，从而改变了他们与Wnt复合体结合的能力；DKK类只结合Wnt受体复合体的一个亚基。sFRPs和DKKs均能激活规则途径。在某些情况下，一种拮抗剂能抑制另一种拈抗剂的作用。研究揭示Wnt的异常激活与多种肿瘤的发生或转移有关，因此深入研究Wnt信号通路，设计出阻断Wnt通路的物质，可为将来癌症的治疗提供一种可行性的途径。
Secreted Wnt glycoproteins are one of the major families of cell signaling molecules and have a dual role in embryogenesis and carcinogenesis.Wnt proteins signals act through canonical pathway and non-canonical pathway.Wnt ligands bind to two distinct families of cell-surface receptors: the Frizzled(Fz) receptor family and the LDL-receptor related protein(LRP) family.Wnt-mediated signals are modulated extracellularly by Wnt antagonists.Wnt antagonists are asecreted proteins that bind to Wnt proteins and inhibit their activities.They can be divided into two groups: one is sFRP family,WIF-1 and Cerberus,another is DKK family.Wnt signaling has clearly emerged as a critical pathway in carcinogenesis.It deserves further study on the components of the Wnt pathway to provide valuable targets for potential anti-cancer therapeutic agents.
张扬清,宋铭晶,邸冉,张连峰. Wnt及其拮抗剂在肿瘤发生中的作用[J].中国比较医学杂志,2006,(1):58~61.
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